If you’ve been collecting new diagnoses the way some people collect coffee mugs—thyroid this, autoimmune that, chronic fatigue, fibromyalgia, mast cell activation—you’re not alone.
For many people, these downstream conditions aren’t the whole story. They’re the body’s SOS signal that something upstream has gone unchecked for too long.
That’s where IACIRS testing and treatment come in. By identifying hidden infections, toxins, and immune triggers, we can uncover why your body is stuck in chronic inflammation—and what needs to shift for real healing to begin.
What Is IACIRS, Briefly?
Infection-Associated Chronic Inflammatory Response Syndrome (IACIRS) describes a pattern where the immune system becomes stuck in chronic activation—not because it’s broken, but because it’s still reacting to underlying infections, toxins, or both.
Over time, this leads to widespread inflammation, immune confusion, and the long list of downstream diagnoses that never seem to fully resolve.
Who Should Consider IACIRS Root Cause Analysis?
1. Those with Vague, Unexplained Symptoms That Never Add Up
Some patients don’t have a single diagnosis—they have a collection of frustrations: fatigue, brain fog, dizziness, rashes, weird neurological sensations, and a revolving door of “normal” test results.
Their symptoms sound like this:
- Profound fatigue and poor recovery after exertion
- Brain fog, poor focus, and short-term memory lapses
- Headaches, light or sound sensitivity
- Muscle and joint pain without clear injury
- Sinus congestion or chronic cough
- Shortness of breath or “air hunger”
- Sleep disturbance and unrefreshing sleep
- Digestive issues, bloating, nausea, or alternating constipation/diarrhea
- Mood changes, anxiety, or irritability
- Skin rashes, itching, or odd sensitivities
- Hormone imbalance or temperature swings
Example:
Emily, 38, had seen more than a dozen specialists for fatigue, dizziness, and rashes. Every scan and lab panel came back “within normal limits.” Her IACIRS testing revealed a trifecta of root causes: internal Candida and Aspergillus overgrowth, Babesia and Borrelia infections, and the inflammatory loop they created. Once treatment addressed both the infections and the fungal burden driving immune activation, her energy, focus, and sleep began to return—slowly but steadily.
2. People Who Keep Collecting Diagnoses
If you’ve been treated for one condition after another—thyroid disease, chronic fatigue, POTS, fibromyalgia—but keep circling back to fatigue, pain, and brain fog, you may be addressing the effects, not the causes.
Root cause analysis helps identify whether your immune system is stuck in defense mode because of hidden infections, toxic exposures, or both.
Example:
Sarah, 42, came in after years of “mystery” autoimmune flares. Her ANA was positive, but no rheumatologic treatment seemed to help. Root cause testing revealed high levels of Aspergillus mycotoxins from long-term mold exposure in her previous home. Once that exposure was addressed and her detox pathways were supported, her joint pain and fatigue finally started to improve.
3. Anyone with Autoimmune or Immune Dysregulation
Autoimmune conditions—like Hashimoto’s, lupus, psoriasis, or rheumatoid arthritis—are often signs that the immune system is overactive in the wrong places and underactive in others.
Chronic infections such as Borrelia, Babesia, or Bartonella can quietly drive this imbalance for years before the first autoimmune marker ever appears.
Example:
David, 37, was diagnosed with psoriasis and reactive arthritis. Topicals and biologics gave short relief, but his symptoms always came roaring back. His IACIRS testing showed chronic Bartonella infection with accompanying mitochondrial dysfunction. After a combination of targeted antimicrobial and mitochondrial support, his inflammation decreased and his energy began to normalize.
4. People with Severe Food Sensitivities or “Mystery Reactions”
When your immune system reacts to everything—foods, fragrances, supplements—it’s not being “overly sensitive.” It’s being overwhelmed.
This often points to mycotoxin or Candida overgrowth, both of which can disrupt gut barrier integrity and confuse immune signaling.
Example:
Anna, 29, was down to ten “safe” foods and still reacted to random meals. Stool microscopy revealed yeast overgrowth, and organic acid testing confirmed high arabinose levels—a fungal metabolite. After three months of systemic antifungal therapy and gradual dietary reintroduction, she could finally eat out with friends again without fear.
5. Those with Recurrent or Chronic Infections
If you’ve had mono that never really went away, or you “catch everything that’s going around,” your immune system might be stuck in a post-infectious loop.
Viruses like Epstein-Barr or stealth infections like Babesia can keep the body in a low-grade alarm state that prevents full recovery.
Example:
Mark, 50, had chronic fatigue and brain fog that began after a viral illness in college. Every year or two, another crash. His IACIRS workup revealed past EBV reactivation plus evidence of Babesia duncani on PCR testing. Treating both the infection and the inflammatory response allowed his energy to stabilize for the first time in decades.
What IACIRS Testing Reveals
IACIRS root cause analysis doesn’t just name infections—it helps map out the immune landscape.
Testing can identify combinations of:
- Fungal overgrowth (Candida, Aspergillus)
- Vector-borne infections (Borrelia, Babesia, Bartonella)
- Toxic exposures (mycotoxins, heavy metals, chemical toxicants)
- Immune and genetic susceptibilities (HLA types, MTHFR, FUT2, etc.)
Together, these findings explain why two people with the same diagnosis can respond so differently to the same treatment.
Why This Approach Works
IACIRS analysis isn’t about adding more supplements or diagnoses.
It’s about finding the few key upstream factors that, once addressed, allow the rest of the system to recalibrate.
When you identify and treat the root irritants—be they fungal, bacterial, or environmental—the immune system can finally quiet down and begin healing the tissues it’s been mistakenly attacking.
The Hopeful Takeaway
IACIRS analysis is for anyone who feels like their health story doesn’t add up anymore—
those who are tired of treating symptoms and ready to look upstream.
The goal isn’t to label, it’s to liberate—to uncover what’s been driving your inflammation so your body can finally remember how to heal.
Because once you understand the “why,” the “how” gets a whole lot easier.